What Medical Conditions CBD for Dogs & Cats Help With
At CBD Care 4 Pets, we are always striving to educate people on the evolving and exciting science of CBD and how it can benefit our pets.
Below is a list of the medical conditions that CBD for dogs and cats can help treat.
The double action of CBD acting on the inhibitory neurotransmission mechanism of the endocannabinoids as well as the natural inhibitory effect of serotonin receptors helps provide for a calmer and less anxious dog or cat.
We already know that the principal effect of cannabinoids in the central nervous system is the tempering of excitatory impulses, generally by inhibiting the release of cyclic-AMP. What this means is that nerve impulses are not sent from one neuron to another. This causes a generalized reduction in brain electrical activity. In short, the brain is able to go into a more relaxed and calmer state, something that you would want to happen in an anxious dog or cat.
The effects of cannabidiol on the 5-NT, the receptor can be likened to the action of commercially-available anti-anxiety drugs. Many of these medications act by stimulating serotonin receptors which, in turn, increases the amount of the inhibitory neurotransmitter in the brain. While one of the effects of serotonin is an elevation of mood, it also has a more pronounced effect on reducing symptoms of anxiety or even fear.
Given that dogs and cats also experience fear or anxiety and that this can be demonstrated in a variety of dog and cat behaviors such as accidents, howling, barking, aggression, chewing, and even muscle tremors, providing them with CBD oil should help ensure a calmer, more peaceful dog or cat.
One of the most sought-after effects of CBD oil is the management of seizures and seizure-like manifestations such as muscle spasms, tremors, and even tics. Seizures or convulsions are typically described as involuntary and uncontrollable contractions of the muscles. These are brought about by the abnormally erratic firing of electrical nerve impulses originating from the brain. Instead of synchronized discharge of nerve impulses, what happens is that there is asynchronicity.
Neurotransmitters are sent out from one neuron to the next, typically in rapid succession but more importantly in a disorganized manner. Since the skeletal muscles are innervated by the peripheral nervous system, they receive these asynchronous, erratic neural messages such that they contract in an uncontrollable fashion. Furthermore, because of the flooding of electrical nerve impulses at the motor endplates of muscles, the contractions are sustained and more forceful than ever.
The problem here is not really in the muscle itself, but rather in the brain. Erratic electrical discharge from the brain does not allow for the efficient distribution of oxygen and glucose to the cells of the brain. If the seizure takes an unusually long time to subside, there is a possibility that the area upon which these abnormal neuronal discharges occur will be greatly deprived of glucose and oxygen. This can lead to substantial reduction in brain tissue oxygenation, a condition medical and veterinary professionals call cerebral hypoxia.
Cerebral hypoxia, if not treated immediately, can lead to irreversible death to the cells of that part of the brain. Stroke may ensue or, in most cases, cerebral hypoperfusion injuries can occur. These can send your dog or cat into a coma if not death.
Cannabidiol can help reduce the severity of convulsions or seizures by preventing the likelihood of hyper-excitable neurons. This helps prevent the abnormal erratic discharges from the brain itself.
There are many theories about pain. However, when it comes to the use of cannabinoids in the management of pain, it is a widely-held observation that its analgesic effects are closely related to the modulation of noradrenaline coming from the brainstem and descending towards the dorsal horn of the spinal cord.
What happens is that these nerve fibers are known to possess GABAergic activity or one that is fully capable of suppressing nerve excitation. When endocannabinoids such as palmitoylethanolamide and anandemide bind to certain receptors in the descending tract of the spinal column, they increase the release of noradrenaline which helps attenuate the pain impulses being processed by the noxious sensory neurons found in the dorsal horn. In other words, they block the processing of these pain impulses by flooding it with noradrenaline while also increasing the inhibitory properties of GABAergic fibers.
This can have significant implications in the management of pain for dogs and cats. When taken together with CBD’s anti-inflammatory properties, one can see that its use in certain chronic canine pain syndromes such as arthritis and other types of pain is a welcome relief for our beloved canine friends.
We believe that cannabidiol has excellent anti-inflammatory effects. This was highlighted in a 2012 research that showed CBD to be especially effective in reducing the symptoms of inflammation in acute lung injury. Another study in the same year also established the crucial anti-inflammatory activities of CBD in the management of acute pancreatitis. These 2 studies supported the earlier 2006 investigation that suggested CBD as an important adjunct in the management of neuropathic pain and chronic inflammation. While it is easy to say that these studies were never performed using dogs or cats as test subjects, using laboratory mice instead, the results nevertheless, underscore the increasing importance of cannabidiol in the management of chronic inflammatory disorders.
The ability of cannabidiol as a powerful anti-inflammatory is strongly associated with the location of the cannabinoid type 2 (CB2) receptors which are mostly found in immune system cells such as monocytes, macrophages, and T-and I, lymphocytes. Its activity on cytokines helps improve the anti-inflammatory action of these immune system cells so that they become very efficient in the management of chronic inflammatory disorders in dogs and cats such as arthritis, inflammatory bowel disorder, canine encephalitis, canine chronic bronchitis, masticatory muscle myositis, acquired myasthenia gravis, and even demodectic mange.
Since one of the cardinal signs of inflammatory processes is the occurrence of pain, the action of cannabidiol on immune system cells can help target two principal problems: pain and inflammation.
Nausea and Vomiting In Dogs and Cats
There are a lot of reasons why dogs or cats can get nausea or exhibit vomiting. In most cases, it is often related to a change in the dog or cat’s usual dietary patterns. However, it can also be brought about by other reasons such as bacterial infections, foreign body ingestion, acute liver failure, intestinal parasitism, pancreatitis, viral infections, inflammation of the gallbladder, and even as effects of undergoing surgery. Whatever the case, nausea and vomiting in dogs and cats are almost always characterized by abnormal gastric and intestinal motility.
There are three ways in which cannabidiol can help dogs and cats with nausea and vomiting. First, by interacting with CB1 receptors, the endogenous cannabinoids released will help inhibit the firing of cAMP into succeeding neurons. This helps reduce the number of electrical impulses traveling towards the gut, reducing gastric and intestinal motility.
Second, since CB2 receptors are also abundant in the gastrointestinal system, their stimulation can help prevent the activity of the immune system on normal gut flora, allowing for the more efficient digestion and absorption of food molecules which can help minimize nausea and vomiting.
Third, the activity of CBD on 5-HT, can also help minimize nausea and vomiting in dogs and cats. Stimulation of the serotonin receptor has been proven to reduce the sensation of nausea while also suppressing the vomiting reflex.
Certain Types of Cancer
One of the most remarkable areas where cannabidiol preparations are now being used on dogs and cats is in the management of certain types of cancers. The area has received widespread attention when several promising studies showed the potentially beneficial effects of CBD on cancer treatment.
For example, the Boston-based Beth Israel Deaconess Medical Center showed in 2011 that cannabidiol has the potential to cause apoptosis or programmed cell death in the neoplastic cells of breast cancer. The Naples, Italy-based University of Naples Federico II published a report indicating that CBD may help prevent the growth, development, and spread of colon cancer tumor cells.
Madrid-based Complutense University went another avenue studying instead the synergistic qualities of cannabidiol in the enhancement of the cancer cell-killing effects of onco-chemotherapeutic agents. The study underscored the activity of CBD in hastening the rate upon which the active ingredients of chemotherapeutic agents are absorbed by cancer cells. At the same time the study observed healthy, normal cells were substantially protected because of their reduced exposure to the chemotherapeutic agents.
Since certain breeds of dogs and cats are also more prone in the development of certain types of cancer, adding CBD oil in their diet or even as regular supplementation should protect them against these cancers.